pentobarbital will lessen the level or effect of eucalyptus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.
There won't be any facts on pregnancy exposures in primates comparable to intervals ahead of the 3rd trimester in human beings.
Sodium valproate and valproic acid appear to lower barbiturate metabolism; hence, barbiturate blood ranges really should be monitored and suitable dosage changes created as indicated.
Griseofulvin: Phenobarbital seems to interfere With all the absorption of orally administered griseofulvin, thus lowering its blood level.
pentobarbital will reduce the extent or impact of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration. Solid or average CYP3A inducers may perhaps lower cobimetinib systemic publicity by >80% and minimize its efficacy.
pentobarbital will minimize the extent or influence of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. The efficacy of hormonal contraceptives might be lessened.
Drug interactions: Most studies of clinically major drug interactions occurring Along with the barbiturates have associated phenobarbital.
pentobarbital will lessen the extent or influence of clozapine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will minimize the extent or influence of terbinafine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
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pentobarbital will lower the extent or result of docetaxel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Not known.
pentobarbital will minimize the level or influence of ethotoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Observe.
pentobarbital will lower the level or outcome of irinotecan liposomal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will minimize the level or effect of fruquintinib by influencing website hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration with reasonable CYP3A4 inducers is unavoidable, go on to administer fruquintinib at recommended dosage.